TITLE:
Acromegaly: Diagnostic and Therapeutic Management Challenges in Senegal
AUTHORS:
Mbaye Sène, Amadou Diop Dia, Bachir Mansour Diallo, Diatou Gueye Dia, Ngoné D. Diack, Nafy Ndiaye, Abdoulaye Leye
KEYWORDS:
Acromegaly, Pituitary, Somatostatin, Senegal
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.16 No.2,
February
14,
2026
ABSTRACT: Introduction: The management of acromegaly faces significant challenges due to the need for precise diagnosis, individualized treatment strategies, and continuous monitoring. We present two case reports illustrating the diagnostic and therapeutic management difficulties of acromegaly in sub-Saharan Africa. Case Reports: Case 1 involved a 65-year-old retired female teacher with a 10-year history of bilateral knee osteoarthritis admitted for hypertension management. Clinical examination revealed typical dysmorphic syndrome and grade II hypertension. Plasma GH and IGF-1 levels were elevated at 17 ng/mL (normal Conclusion: These observations highlight two critical areas requiring improvement in acromegaly management strategies in sub-Saharan Africa: first, the use of advanced imaging modalities such as FET-PET/MRI and 11C-methionine PET when conventional MRI is inconclusive; second, improving accessibility to somatostatin analogs and other specialized treatments to prevent irreversible complications.