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I. Troch, F. Breitenecker and M. Graeff, “Computing Optimal Controls for Systems with State and Control Constraints,” Proceedings of the IFAC Control Applications of Nonlinear Programming and Optimization, Paris, 7-9 June 1989, pp. 39-44.

has been cited by the following article:

• TITLE: Bezier Control Points Method to Solve Scheduling of Injections of Immunotherapeutic Agents

  AUTHORS: Fateme Ghomanjani

  KEYWORDS: Immunotherapy; Bezier Control Points; Constrained Optimal Control

  JOURNAL NAME: Intelligent Control and Automation, Vol.3 No.1, February 28, 2012

  ABSTRACT: Cancer immunotherapy aims at enhancing immune system to defend against the tumor. However, it is associated with injecting small doses of tumor-bearing molecules or even using drugs. The problem is that how to schedule these injections effectively and/or how to apply drugs in a way to decrease toxic side effects of drugs such that the tumor growth to be stopped or at least to be limited. Here, the theory of optimal control has been applied to find the optimal schedule of injections of an immunotherapeutic agent against cancer. The numerical method employed works for any dynamic linear system and has almost precise solution. In this work, it was tested for a well known model of the tumor immune system interaction.