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Fontaine, E., Barnoud, D., Schwebel, C. and Leverve, X. (2002) Place des anti-oxydants dans la nutrition du patient septiqueAntioxidants in critically ill patients. Réanimation, 11, 411-420.
https://doi.org/10.1016/s1624-0693(02)00269-4

has been cited by the following article:

• TITLE: Antiradical and Sedative Non-Hypnotic Effect of Tikoni Tea Extract from Leaves of Vitex madiensis Oliv. (Lamiaceae) Locally Used in Congolese Villages

  AUTHORS: Gélase Fredy Nsonde Ntandou, Eric Motondo

  KEYWORDS: Vitex madiensis, Tikoni Tea, Aqueous Extract, Antioxidant, Sedative

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.17 No.1, January 30, 2026

  ABSTRACT: The present study aimed to contribute to the valorization of Congolese medicinal drugs and food plants. This study shows that the aqueous extract of Tikoni tea (200 and 400 mg/kg) significantly reduces motor activity and increases the duration of barbiturate-induced sleep in mice compared to diazepam (10 mg/kg). However, diazepam decreased time to sleep onset, whereas the extract increased it. The extract therefore has no hypnotic effect; the increase in latency time could be a stimulating effect. This study also revealed that this tea extract possesses free radical scavenging properties with an IC50 of 8.54 mg/mL, which are thought to be linked to the presence of secondary metabolites in this plant.