TITLE:
Kallmann Syndrome: Review of Two Cases in Brothers
AUTHORS:
Djaury Dadji, Ildjima Kadallah, Adrienne Ngaringuem, Ntsoli Gaelle, Djohara Barka, Dessainbe Djoui, Micondo Kouamé Hervé
KEYWORDS:
Kallmann Syndrome, N’Djamena, Chad
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.16 No.1,
January
26,
2026
ABSTRACT: Background: Kallmann syndrome is a rare genetic disorder characterized by congenital hypogonadotropic hypogonadism associated with anosmia. We report two cases of Kallmann syndrome in two brothers followed at the University Mother and Child Hospital of N’Djamena. Case Presentation: An 18-year-old young man presented with micropenis (40 mm), bilateral cryptorchidism, anosmia, and severe growth retardation (height 146 cm, −4 SD). Biological investigations revealed hypogonadotropic hypogonadism (FSH: 0.42 IU/ml, LH 2). After 5 injections, significant clinical improvement was observed: increase in penile length to 70 mm and 65 mm respectively, with regular erections, ejaculation, and testicular descent. Conclusion: Kallmann syndrome, although rare, warrants systematic consideration in adolescents presenting with delayed puberty, anosmia, and micropenis.