TITLE:
Congenital Factor VII Deficiency Revealed in the Neonatal Period: A Case Report at CHNEAR
AUTHORS:
Maryame Aida Kane, Awa Kane, Ibrahima Diop, Mame Awa Ndao, Sokhna Aissatou Touré, Sadio Konaté, Fatima Zahra Sahib, Amadou Sow, Aminata Mbaye, Aida Sarr, Souleye Sow, Abdou Aziz Faye, Mame Fama Niang, Diary Sow, Djibril Boiro, Indou Deme Ly, Babacar Niang, Abou Ba, Idrissa Demba Ba, Pape Moctar Faye, Amadou Lamine Fall, Saliou Diop, Ousmane Ndiaye
KEYWORDS:
Factor VII, Neonatal Hemorrhage, Congenital, Autosomal Recessive, Hemostasis
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.16 No.1,
January
13,
2026
ABSTRACT: Congenital factor VII deficiency is a rare, autosomal recessive disorder with an estimated prevalence of 1 in 1,000,000. We report the case of a female newborn, born to second-degree consanguineous parents, admitted at 22 days of age for management of a subarachnoid hemorrhage. Hemostasis testing revealed a prothrombin time (PT) of 16%, with a preserved activated partial thromboplastin time (aPTT). Coagulation testing demonstrated an isolated factor VII deficiency. Through this case, we highlight the clinical, biological, and therapeutic characteristics of this anomaly during the neonatal period.