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R. H. Brodkin and J. Bleiberg, “Sensitivity to Topically Applied Vitamin E,” Archives of Dermatology, Vol. 92, No. 1, 1965, pp. 76-77. doi:10.1001/archderm.1965.01600130082016

has been cited by the following article:

• TITLE: Allergic Contact Dermatitis Syndrome Due to Tocopherol Acetate, in Addition to Glycyrrhetinic Acid

  AUTHORS: Kentaro Ohko, Akiko Ito, Masaaki Ito

  KEYWORDS: Allergic Contact Dermatitis; Tocopheryl Acetate; Vitamin E; Enoxolone; 18-Glycyrrhetinic Acid

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.2 No.1, March 28, 2012

  ABSTRACT: Natural vitamin E is suggested to have an antioxidant function. However, the synthetic form of vitamin E, DL-tocopherol, which has been widely used in topical ointments, may cause allergic contact dermatitis. Here, we report a case of allergic contact dermatitis with erythema multiforme-like eruption caused by a topical ointment. Patch testing indicated a positive allergic reaction to an anti-inflammatory ointment the patient had been using and its ingredient, DL-alpha-tocopheryl acetate (vitamin E). In addition, a positive reaction to glycyrrhetinic acid was observed. Both vitamin E and glycyrrhetinic acid are useful ingredients of topical applications. However, the possibility that both can cause contact dermatitis, albeit rarely, should be considered.