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Gnisci, A., Rua, S., Courbiere, B., Cravello, L., Gamerre, M. and Agostini, A. (2011) Plasma Creatine Phosphokinase Level May Predict Successful Treatment after a Single Injection of Methotrexate for Ectopic Pregnancy. Fertility and Sterility, 95, 2131-2133.
https://doi.org/10.1016/j.fertnstert.2010.12.020

has been cited by the following article:

• TITLE: Correlation between hCG Kinetics and the Effectiveness of Methotrexate in the Management of Ectopic Pregnancies

  AUTHORS: Oum Elkheir Soltana Senouci, Fadl-Allah Aboubekr, Hind Bedjaoui, Mimouna Messaoud, Ikram Tachema

  KEYWORDS: Methotrexate, Ectopic Pregnancy, hCG

  JOURNAL NAME: Open Access Library Journal, Vol.13 No.1, January 5, 2026

  ABSTRACT: Purpose: To evaluate a therapeutic monitoring strategy for ectopic pregnancies treated with methotrexate (MTX) injection based on hCG level kinetics, in order to identify patients at low risk of treatment failure. Materials and Methods: This series of 14 cases allowed us to evaluate the success rate of therapeutic management with a single injection of methotrexate (MTX), based on the kinetics of hCG levels. The protocol stipulated that if the decrease was greater than 20% between days 1 and 4, follow-up was limited to an hCG measurement one month later. Results: Among the 14 patients treated, the overall success rate of MTX treatment was 85.71%. Conclusion: Our protocol allows us to select patients at low risk of failure of single-dose MTX treatment, and to offer them less restrictive monitoring.