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Hajenius, P., Engelsbel, S., Mol, B., van der Veen, F., Ankum, W., Bossuyt, P., et al. (1997) Randomised Trial of Systemic Methotrexate versus Laparoscopic Salpingostomy in Tubal Pregnancy. The Lancet, 350, 774-779.
https://doi.org/10.1016/s0140-6736(97)05487-1

has been cited by the following article:

• TITLE: Correlation between hCG Kinetics and the Effectiveness of Methotrexate in the Management of Ectopic Pregnancies

  AUTHORS: Oum Elkheir Soltana Senouci, Fadl-Allah Aboubekr, Hind Bedjaoui, Mimouna Messaoud, Ikram Tachema

  KEYWORDS: Methotrexate, Ectopic Pregnancy, hCG

  JOURNAL NAME: Open Access Library Journal, Vol.13 No.1, January 5, 2026

  ABSTRACT: Purpose: To evaluate a therapeutic monitoring strategy for ectopic pregnancies treated with methotrexate (MTX) injection based on hCG level kinetics, in order to identify patients at low risk of treatment failure. Materials and Methods: This series of 14 cases allowed us to evaluate the success rate of therapeutic management with a single injection of methotrexate (MTX), based on the kinetics of hCG levels. The protocol stipulated that if the decrease was greater than 20% between days 1 and 4, follow-up was limited to an hCG measurement one month later. Results: Among the 14 patients treated, the overall success rate of MTX treatment was 85.71%. Conclusion: Our protocol allows us to select patients at low risk of failure of single-dose MTX treatment, and to offer them less restrictive monitoring.