TITLE:
Endometrial Hyperplasia with Conservative Treatment Using the Progestin or EP Agents, Compared to Cases that Worsen during Observation
AUTHORS:
Kenji Niwa, Saki Tsurue, Kentaro Niwa, Yoh Hayasaki, Masanori Isobe, Takuji Tanaka
KEYWORDS:
Endometrial Hyperplasia, Progestin, EP, PTEN-Null
JOURNAL NAME:
Open Journal of Pathology,
Vol.16 No.1,
January
4,
2026
ABSTRACT: A total of 157 patients were included in this study, comprising 147 with simple Endometrial Hyperplasia (EH) and 10 with complex EH. All patients treated cyclically with progestin or Estrogen-Progestin (EP) exhibited regression of EH after 3 or 4 treatment courses. The relapse rate in patients treated cyclically with progestin was significantly lower than that in those treated with EP for simple EH (P