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J. Patole, U. Sandbhor, S. Padhye, D. N. Deobagkar, C. Anson and A. E. Powell, “Structural Chemistry and in Vitro Antitubercular Activity of Acetylpyridine Benzoyl Hydrazone and Its Copper Complex against Mycobacterium smegmatis,” Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 1, 2003, pp. 51-55. doi:10.1016/S0960-894X(02)00855-7

has been cited by the following article:

• TITLE: The Reaction of Cyanoacetylhydrazine with Chloroacetone: Synthesis of 1,2,4-Triazine, 1,3,4-Oxadiazine and Their Fused Derivatives with Antitumor Activities

  AUTHORS: Rafat M. Mohareb, Eman M. Samir

  KEYWORDS: 1, 2, 4-Triazine; 1, 3, 4-Oxadiazine; Pyrazole; Antitumor

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.2 No.1, March 28, 2012

  ABSTRACT: The reaction of cyanoacetylhydrazine with chloroacetone gave the N-(1-chloropropan-2-ylidene)-2-cyanoacetohy- drazide. This compound reacted with either hydrazine hydrate or phenylhydrazine to give the corresponding 1,2,4-tri- azine derivatives. On the other hand, its reaction with either benzenediazonium chloride or benzaldehyde gave in each case the 1,3,4-oxadiazine derivatives. Moreover, the reaction of the cyanoacetylhydrazine with 2-boromocyclohexa- none gave the corresponding hydrazine-hydrozon derivative. The antitumor evaluation of the newly synthesized prod- ucts against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was recorded. Some of the tested compounds showed activities which was higher than the reference doxorubicin.