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M. A. Gaston, L. R. Dias, A. C. Freitas, A. L. Miranda and P. Barreiro, “Synthesis and Analgesic Properties of New 4-Arylhydrazone 1-H Pyrazole [3,4-b] Pyridine Derivatives,” Pharmaceutica Acta Helvetiae, Vol. 71, No. 2, 1996, pp. 213-219. doi:10.1016/0031-6865(96)00012-X

has been cited by the following article:

• TITLE: The Reaction of Cyanoacetylhydrazine with Chloroacetone: Synthesis of 1,2,4-Triazine, 1,3,4-Oxadiazine and Their Fused Derivatives with Antitumor Activities

  AUTHORS: Rafat M. Mohareb, Eman M. Samir

  KEYWORDS: 1, 2, 4-Triazine; 1, 3, 4-Oxadiazine; Pyrazole; Antitumor

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.2 No.1, March 28, 2012

  ABSTRACT: The reaction of cyanoacetylhydrazine with chloroacetone gave the N-(1-chloropropan-2-ylidene)-2-cyanoacetohy- drazide. This compound reacted with either hydrazine hydrate or phenylhydrazine to give the corresponding 1,2,4-tri- azine derivatives. On the other hand, its reaction with either benzenediazonium chloride or benzaldehyde gave in each case the 1,3,4-oxadiazine derivatives. Moreover, the reaction of the cyanoacetylhydrazine with 2-boromocyclohexa- none gave the corresponding hydrazine-hydrozon derivative. The antitumor evaluation of the newly synthesized prod- ucts against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was recorded. Some of the tested compounds showed activities which was higher than the reference doxorubicin.