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Grignon, D.J., Ro, J.Y., Ayala, A.G., Shum, D.T., Ordóñez, N.G., Logothetis, C.J., et al. (1992) Small Cell Carcinoma of the Urinary Bladder. A Clinicopathologic Analysis of 22 Cases. Cancer, 69, 527-536.
https://doi.org/10.1002/1097-0142(19920115)69:2<527::aid-cncr2820690241>3.0.co;2-7

has been cited by the following article:

• TITLE: Metastatic Small Cell Neuroendocrine Carcinoma of the Bladder: Case Report and Literature Review

  AUTHORS: Abir Oufrid, Basma Aabboub, Lamiae Amaadour, Karima Oualla, Zineb Benbrahim, Samia Arifi, Nawfel Mellas

  KEYWORDS: Bladder, Neuroendocrine Carcinoma, Small Cell, Metastases, Chemotherapy

  JOURNAL NAME: Journal of Cancer Therapy, Vol.17 No.1, December 30, 2025

  ABSTRACT: Background: Small cell neuroendocrine carcinoma of the bladder (SCNECB) is a rare entity, accounting for less than 1% of bladder tumors. It progresses rapidly and has a poor prognosis. Case Presentation: We report the case of a 62-year-old man, a chronic smoker, admitted for gross hematuria that had been developing for a month. An abdominal-pelvic CT scan revealed an infiltrating bladder mass associated with liver metastases. RTUV confirmed the diagnosis of small cell neuroendocrine carcinoma through immunohistochemistry: chromogranin A, synaptophysin, and CD56 positive, Ki-67 at 80%. The patient received six cycles of cisplatin-etoposide, with an initial partial response. The disease then progressed rapidly, leading to the patient’s death eight months after diagnosis. Conclusion: This case illustrates the early metastatic presentation and rapid progression of small cell neuroendocrine carcinoma of the bladder. Despite platinum-based chemotherapy, the prognosis remains poor, especially in resource-limited countries.