TITLE:
Peripheral Neuropathies Associated with Gammopathies in the Outpatient Clinic of the Neurology Department at the University Hospital Center of Libreville: Study of Two Cases and Literature Review
AUTHORS:
Nelly Diouf Mbourou, Annick Nsounda, Chermine Mboumba Mboumba, Pupchen Gnigone, Jennifer Nyangui Mapaga, Grass Mambila, Michel Arnaud Saphou Damon, Ibrahima Camara, Mael Ndao Eteno, Carl Mialoundama, Marina Guarisco, Keila Ondimba, Philomène Kouna Ndouongo
KEYWORDS:
Peripheral Neuropathy-Gammopathy-Libreville
JOURNAL NAME:
Neuroscience and Medicine,
Vol.16 No.4,
December
26,
2025
ABSTRACT: Introduction: Peripheral neuropathies associated with gammopathies are common after the age of 55 years. However, serum protein electrophoresis is not systematically performed in the etiological workup of neuropathy. Objective: to describe cases the clinical profiles of patients with peripheral neuropathy and co-occuring gammopathy and highlight associated diagnostic challenges in our clinical setting. Methodology: This retrospective and prospective descriptive study, conducted in the neurology department of CHUL, reported observations of two female patients, aged 73 and 62 years, respectively, who presented in consultation with clinical signs suggestive of peripheral neuropathy, subsequently confirmed by electroneuromyography, and whose investigations revealed gammopathy. Results and Conclusion: Peripheral neuropathies associated with gammopathies should be systematically investigated, as they are not uncommon. They primarily affect elderly women, who often present with bilateral carpal tunnel syndrome, with or without an associated neuropathy. Etiological evaluation, in our context, is often limited once additional diagnostic tests are pursued. However, in the presence of certain gammopathies, it is essential to rule out malignant hematological disorders.