Article citationsMore>>

Dahlén, S.E., Björk, J., Hedqvist, P., Arfors, K.E., Hammarström, S., Lindgren, J.A., et al. (1981) Leukotrienes Promote Plasma Leakage and Leukocyte Adhesion in Postcapillary Venules: In Vivo Effects with Relevance to the Acute Inflammatory Response. Proceedings of the National Academy of Sciences of the United States of America, 78, 3887-3891.
https://doi.org/10.1073/pnas.78.6.3887

has been cited by the following article:

• TITLE: Early Detection of Colonic Anastomotic Leakage in a Swine Model Using Continuous pH Monitoring

  AUTHORS: Nour Helwa, Manaswi Sharma, Manasvi Vanama, Diana Khater, Olivia Rennie, Youssef Helwa, Abdallah El-Falou, Joao Rezende-Neto

  KEYWORDS: Anastomotic Leak, StreamTM Platform, pH, Electrical Conductivity, Early Prediction

  JOURNAL NAME: Open Journal of Gastroenterology, Vol.15 No.12, December 25, 2025

  ABSTRACT: Background: Anastomotic leaks (AL) are a deadly postoperative complication. This study evaluated the efficacy of StreamTM Platform, a medical device designed to provide early prediction of AL using changes in peritoneal fluid pH and electrical conductivity (EC). Methods: StreamTM Platform was attached to the JP drain of 17 Yorkshire pigs, continuously measuring pH and EC or peritoneal effluent in a model of colorectal AL. Anastomotic leaks were surgically induced and confirmed through re-laparotomy. Results: Significant differences in pH were observed between experimental and sham animals two hours following leak induction via continuous measurements (P = 0.02857), at the 24-hour time point in reservoir fluid (P = 0.008), and during final peritoneal fluid collection at re-laparotomy (P = 0.024). Conclusion: This study illustrates the potential of continuous pH monitoring for early detection of anastomotic leaks, using a non-invasive technology—StreamTM Platform—in a model that closely resembles human physiology.