TITLE:
Analysis of the Achievement of Target Plasma Concentrations and Its Influencing Factors during Piperacillin-Tazobactam Treatment in Elderly Patients with Severe Pneumonia
AUTHORS:
Li He, Qin Cao, Cui Wei, Shenjue Chen
KEYWORDS:
Severe Pneumonia, Piperacillin-Tazobactam, Achievement of Target Plasma Concentration, Influencing Factors
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.12,
December
24,
2025
ABSTRACT: Objective: To investigate the achievement of target plasma concentrations and related influencing factors in elderly patients with Severe Pneumonia (SP) during piperacillin-tazobactam treatment. Methods: A retrospective analysis was conducted on the medical records of 82 elderly patients with severe pneumonia admitted to our hospital from August 2023 to August 2025. All enrolled patients received intravenous piperacillin-tazobactam. Piperacillin plasma concentrations were monitored, and multivariate logistic regression was used to analyze factors influencing the achievement of target plasma concentrations for piperacillin-tazobactam. Results: Among the 82 SP patients treated with piperacillin-tazobactam, target plasma concentrations were achieved in 39 cases (47.56%) and not achieved in 43 cases (52.44%). The target achievement group had a higher proportion of q6h dosing frequency, longer infusion time, and higher Albumin (Alb) levels, while C-Reactive Protein (CRP), Serum creatinine (Scr), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Total Bilirubin (TBIL), APACHE II score, and SOFA score were lower compared to the control group (P