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Fried, S.D., Fujishima, K., Makarov, M., Cherepashuk, I. and Hlouchova, K. (2022) Peptides before and during the Nucleotide World: An Origins Story Emphasizing Cooperation between Proteins and Nucleic Acids. Journal of The Royal Society Interface, 19, Article ID: 20210641.
https://doi.org/10.1098/rsif.2021.0641

has been cited by the following article:

• TITLE: Experimental and Computational Study of Amino Acid Synthesis from Acetonitrile and Glycine Oligomers on a Carbonate Surface under UV-C Radiation: Implications for Titan and Early Earth

  AUTHORS: Karina Rosario Ortiz Leyra, Alejandro Heredia Barbero

  KEYWORDS: Early-Earth, Titan, Prebiotic, Aminoacids, Tholins

  JOURNAL NAME: Natural Science, Vol.17 No.11, December 23, 2025

  ABSTRACT: This study investigates prebiotic chemistry on Titan and Early Earth using experimental methods, including Differential Scanning Calorimetry (DSC) and Fourier-Transform Infrared Spectroscopy (FTIR), which are relevant for identifying molecular structures and thermal stability of amino acids. Analyses of glycine and acetonitrile with calcium carbonate under UV-C radiation show that glycine oligomers facilitate stable amino acid synthesis. We conclude that Titan’s environment can directly support the formation of life-relevant molecules, revealing a plausible pathway for chemical evolution analogous to that on Early Earth.