TITLE:
Skin Priming with Polyrevitalising Solution Could Improve the Efficacy of Radiofrequency Microneedling on Skin Rejuvenation: A Comparative Split Face Randomised Pilot Study
AUTHORS:
Mostafa Mahdavinia, Kamran Balighi, Elham Rahimi, Hanane Issa, Roula Khalil, Petra Bou Khalil, Ferial Fanian
KEYWORDS:
Aging, Biorevitalising Solution, Radiofrequency, Skin Quality, RF Microneedling
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.15 No.4,
December
23,
2025
ABSTRACT: Background/Aim: Skin ageing is a complex process influenced by diverse intrinsic and extrinsic factors, leading to visible changes such as wrinkles, fine lines, pigmentation irregularities, and loss of elasticity. Radiofrequency (RF) microneedling devices are popular non-invasive tools for the treatment of wrinkles, stimulating collagen and tightening skin. As skin ages, it also loses hydration and biorevitalising solutions have been shown to combat this effect. The aim of this split-face, comparative, monocentric, randomised pilot study was to assess the synergistic efficacy and tolerability of combining biorevitalising solution with non-ablative radiofrequency (RF) microneedling for facial rejuvenation. Study design/Methods: One side of each participant’s face (N = 6) was injected with biorevitalising solution at baseline. Both sides then received Virtue RF treatment on Days 7 - 10, 30 and 50. After each RF session, topical biorevitalising solution was applied on the same side as the initial baseline injection. Evaluations were conducted at baseline, Days 7 - 10, 30, 50 and 60, using clinical scoring, the Global Aesthetic Improvement Scale (investigator and subject), photography and local reaction monitoring. Results: Compared to RF microneedling alone, the combined treatment with biorevitalising solution resulted in greater improvements in skin tonicity, hydration, radiance, and a significant reduction in wrinkle scores. Treatment was well tolerated. Conclusion: The preliminary results of this pilot study support the use of biorevitalising solution in combination with RF microneedling as an effective approach for skin rejuvenation therapy.