TITLE:
Clinical Improvement in Patients with Irritable Bowel Syndrome and Low Level of DAO after Supplementation with Bovine Colostrum and Vitamins: A Case Series
AUTHORS:
Samantha di Geso, Agostina Iannicelli, Luigi Alberto Marrari
KEYWORDS:
Irritable Bowel Syndrome, DAO, Histamine Intolerance, Vitamins, IMOpro Colostrum Plus®
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.15 No.12,
December
16,
2025
ABSTRACT: Background: Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder often associated with altered Diamine Oxidase (DAO) activity and histamine intolerance. The aim of this study was to evaluate the effect of bovine colostrum and vitamins, on DAO levels and clinical symptoms in patients with IBS. Methods: Four patients (two IBS-C, one IBS-D and one IBS-M) were evaluated for DAO activity and clinical symptoms before and after 90 days from treatment supplementation with bovine colostrum and vitamins and specific anti-inflammatory diet. Clinical improvements, weight variation, and gastrointestinal symptoms were recorded. Results: All patients showed significant improvement in DAO levels and reduction of IBS-related symptoms. Patients also reported improved energy levels and tolerance to previously problematic foods. Conclusion: Supplementation with bovine colostrum and vitamins and specific anti-inflammatory diet was associated with increased DAO activity and marked clinical improvement in patients with IBS. Further studies on larger populations are warranted.