TITLE:
Polymixin-B hemoperfusion in a case intolerant to conventional antibiotic therapy
AUTHORS:
Gilnardo Novelli, Vincenzo Morabito, Giancarlo Ferretti, Simone Novelli, Franco Ruberto, Milena Pernice, Cristina Cristina Donfrancesco, Perluigi Benedetti Panici
KEYWORDS:
Sepsis; Endotoxin Activity; Antibiotics
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.5 No.3,
March
27,
2012
ABSTRACT: In this study we document how it was possible to resolve the septic complications of abdominal surgery, subjecting a patient severely allergic to intravenous antibiotics. We performed the hemoperfusion with polymyxin-B columns (PMX-DHP), guiding the therapy by assaying endotoxin activity and evaluating the clinical status of the patient after each session of PMX-DHP. The stabilization of hemodynamic and inflammatory frameworks were immediately observed after the PMX-DHP. The patient could be safely discharged five days after the discontinuation of the therapy. Our findings confirms data already published in literature concerning the effectiveness of PMX-DHP.