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Marshall, J.C., Foster, D., Vincent, J.L., et al. (2004) Diagnostic and prognostic implications of endotoxemia in critical illness: Results of the MEDIC study. Journal of Infectious Diseases, 190, 527-534. doi:10.1086/422254

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• TITLE: Polymixin-B hemoperfusion in a case intolerant to conventional antibiotic therapy

  AUTHORS: Gilnardo Novelli, Vincenzo Morabito, Giancarlo Ferretti, Simone Novelli, Franco Ruberto, Milena Pernice, Cristina Cristina Donfrancesco, Perluigi Benedetti Panici

  KEYWORDS: Sepsis; Endotoxin Activity; Antibiotics

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.5 No.3, March 27, 2012

  ABSTRACT: In this study we document how it was possible to resolve the septic complications of abdominal surgery, subjecting a patient severely allergic to intravenous antibiotics. We performed the hemoperfusion with polymyxin-B columns (PMX-DHP), guiding the therapy by assaying endotoxin activity and evaluating the clinical status of the patient after each session of PMX-DHP. The stabilization of hemodynamic and inflammatory frameworks were immediately observed after the PMX-DHP. The patient could be safely discharged five days after the discontinuation of the therapy. Our findings confirms data already published in literature concerning the effectiveness of PMX-DHP.