TITLE:
Ozone Therapy in Dentistry: A Literature Review
AUTHORS:
Salma Mahboub, Fatiha Rhrich Haddout
KEYWORDS:
Ozone, Therapy, Treatment, Dentistry, Odontology
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.12,
December
9,
2025
ABSTRACT: Ozone therapy is a bio-oxidative therapeutic approach used in dentistry for its antimicrobial, healing, and immunostimulating properties. This literature review aims to evaluate the clinical applications, effectiveness, and future perspectives of ozone in various dental specialties. A bibliographic search was conducted in PubMed, ScienceDirect, and Google Scholar between 2015 and 2025 using the following Boolean equation: (ozone OR ozone) AND (therapy OR treatment) AND (dentistry OR odontology). Thirty-eight articles were included according to specific criteria. The results show that ozone has beneficial effects in the prevention and treatment of dental caries, endodontic disinfection, periodontology, oral surgery, management of postoperative pain, and healing of oral lesions. However, despite these promising outcomes, the standardization of treatment protocols remains necessary to confirm their clinical effectiveness and long-term safety.