TITLE:
Updates to the Clinical Practice Guidelines for the Management of Overweight and Obesity in Saudi Arabia: Year 2024
AUTHORS:
Abdulrahman Alshaikh, Ali A. Alshehri, Hussein Elbadawi, Mohammed Aldawish, Faisal Abalkhail, Fahad Alsabaan, Meshal Alaqeel, Metib Alotaibi, Fahad Aljuraibah, Abdullah Abdulaziz Al Wabel, Abdullah Fayez Badawi, Ahmad Mohammed Alsumaily, Khalid Kelis, Hussein S. Alamri, Lamya Alzubaidi, Ahmed Al-Jedai, Emad R. Issak, Saud Alsifri
KEYWORDS:
Obesity, Saudi Arabia, GLP-1 Receptor Agonists, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Guidelines
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.16 No.12,
December
9,
2025
ABSTRACT: The global obesity epidemic, fueled by lifestyle changes and declining physical activity, is a significant public health challenge. In Saudi Arabia, obesity rates are among the highest worldwide, with projections indicating a prevalence of 57% in adults and 38% in children by 2035. Obesity poses significant health risks, including diabetes, cardiovascular diseases, and Metabolic dysfunction-associated steatotic liver disease, and imposes a substantial economic burden, with direct and indirect costs exceeding $19 billion annually. Timely intervention is crucial. The updated Saudi Guidelines for Obesity prioritize early diagnosis and management, emphasizing behaviour modifications, education, and the adoption of evidence-based pharmacologic and surgical options. Notable advancements in pharmacotherapy, such as GLP-1 receptor agonists like semaglutide, offer a ray of hope. They have been shown to not only reduce cardiovascular risk but also potentially benefit renal disease, halt the progression of MASLD, and improve mechanical complications related to obesity, particularly knee osteoarthritis, as well as numerous benefits beyond weight loss. The guidelines advocate for a multifaceted approach that incorporates public awareness campaigns, family-centered interventions, and advanced therapeutic strategies to mitigate the health and economic impacts of obesity. These comprehensive updates aim to improve population health and reduce obesity-related complications in Saudi Arabia.