TITLE:
Necrotizing Sarcoid Granulomatosis with Concurrent Ankylosing Spondylitis: A Case Mimicking Pulmonary Tuberculosis
AUTHORS:
Dineshpersad Jiawan, Rakesh Bansie, Mikel Chan, Iswardath Thakoer, Fitzgerald A. Gopie
KEYWORDS:
Case Report, Necrotizing Sarcoid Granulomatosis, Ankylosing Spondylitis, Tuberculosis
JOURNAL NAME:
Journal of Tuberculosis Research,
Vol.13 No.4,
December
2,
2025
ABSTRACT: Histologic tuberculosis eventually turned out to be necrotizing sarcoid granulomatosis, a rare disease. A retired TB ward nurse with recurrent uveitis, a positive TST, pulmonary masses and skeletal pain was diagnosed with clinical tuberculosis (TB) and treated with first line tuberculostatic drugs, but the chest X-ray did not improve after treatment completion. Ensuing reassessment of the pulmonary biopsy resulted in a diagnosis of pulmonary necrotizing sarcoid granulomatosis (NSG) and concurrent ankylosing spondylitis (AS), a very rare combination of inflammatory diseases. Uveitis can be a symptom of TB or AS or NSG, the last being a rare disorder of unknown etiology, mimicking tuberculosis.