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Ikonomidis, I., Tzortzis, S., Andreadou, I., Paraskevaidis, I., Katseli, C., Katsimbri, P., et al. (2014) Increased Benefit of Interleukin-1 Inhibition on Vascular Function, Myocardial Deformation, and Twisting in Patients with Coronary Artery Disease and Coexisting Rheumatoid Arthritis. Circulation: Cardiovascular Imaging, 7, 619-628.
https://doi.org/10.1161/circimaging.113.001193
has been cited by the following article:
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TITLE:
Current Indications for IL-1 Inhibition in Rheumatology
AUTHORS:
Soukaina Zaher, Kawtar Nassar, Ahlam Ajerouassi, Wafae Rachidi, Saadia Janani
KEYWORDS:
Interleukin 1, Anti-Interleukin 1, Auto-Inflammatory Disease, Anakinra, Canakinumab, Rilonacept
JOURNAL NAME:
Open Journal of Rheumatology and Autoimmune Diseases,
Vol.15 No.4,
November
28,
2025
ABSTRACT: Interleukin-1 pro-inflammatory cytokines orchestrate local and systemic inflammatory responses in several diseases. Three therapeutic agents for reducing the activities of IL-1 are currently available. Conditions effectively treated with IL-1 blocking agents range from classical rheumatic diseases to autoinflammatory syndromes. In addition, IL-1 antagonism is also effective against other very common diseases, namely cardiovascular disease and type 2 diabetes, which are also co-morbidities, frequently found in patients with rheumatic diseases. Therefore, inhibition of IL-1 may provide clinical benefits beyond the efficacy of osteoarticular manifestations. The purpose of this article is to review the indications for anti-interleukins 1 in rheumatology.