TITLE:
A Single-Center Retrospective Cohort Study on the Correlation between the Oxford Classification of IgA Nephropathy Based on Multimodal Pathological Features and Clinical Prognosis
AUTHORS:
Fengling Lu, Lina Huang, Binbin Deng, Xiaoyue Zhao, Ying Cen, Junxue Ma
KEYWORDS:
IgA Nephropathy, Oxford Classification, Pathological Features, Clinical Prognosis, Retrospective Study
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.18 No.12,
November
28,
2025
ABSTRACT: Objective: To explore the intrinsic relationship between the Oxford Classification (MEST-C) of IgA Nephropathy (IgAN) and patients’ baseline clinical indicators, combined with multimodal pathological findings. Methods: Clinical and pathological data from 40 patients with primary IgAN diagnosed by renal biopsy at our hospital between April 2021 and December 2024 were retrospectively collected. Pathological presentations, including the Oxford Classification, immunofluorescence deposition patterns, and electron microscopy features, were analyzed and correlated with clinical indicators such as 24-hour urine protein (24 hUP), estimated glomerular filtration rate (eGFR), and hypertension. Results: Among the 40 patients, the M1 (95.0%) and S1 (77.5%) scores of the Oxford Classification were the most prevalent. Correlation analysis between pathology and clinical indicators showed that in the patient group with global glomerulosclerosis ≥ 25%, the proportions of 24 hUP ≥ 1 g, eGFR 2, and concomitant hypertension were 85.0%, 75.0%, and 85.0%, respectively, all higher than those in the group with global glomerulosclerosis