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Guo, J., Zhan, S., Lees-Miller, J.P., Teng, G. and Duff, H.J. (2005) Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37 degrees C and 42 degrees C. Heart Rhythm, 2, 860-866. doi:10.1016/j.hrthm.2005.04.029

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• TITLE: Non genetic risk factors of long-QT syndrome

  AUTHORS: Ewa Moric-Janiszewska, Grzegorz Hibner

  KEYWORDS: Long-QT Syndrome Acquired; Congenital; Drug-Induced; Non-Genetic Factors; Environmental Factors

  JOURNAL NAME: Open Journal of Genetics, Vol.2 No.1, March 2, 2012

  ABSTRACT: The purpose of the present study is to provide guidelines regarding risk factors that may worsen the Long-QT Syndrome (LQTS), based on available literature. This review evaluates the current knowledge on these risk factors of acquired LQTS, with an emphasis on non genetic risk factors, including environmental factors. PubMed was searched for literature in English from 1999 to 2011 on the molecular and clinical studies of Long-QT syndrome. We agree, with recent investigations described in the literature, that variety of factors, inherited or environmental, can influence expression of ion channel proteins with impact on repolarization.