TITLE:
Non genetic risk factors of long-QT syndrome
AUTHORS:
Ewa Moric-Janiszewska, Grzegorz Hibner
KEYWORDS:
Long-QT Syndrome Acquired; Congenital; Drug-Induced; Non-Genetic Factors; Environmental Factors
JOURNAL NAME:
Open Journal of Genetics,
Vol.2 No.1,
March
2,
2012
ABSTRACT: The purpose of the present study is to provide guidelines regarding risk factors that may worsen the Long-QT Syndrome (LQTS), based on available literature. This review evaluates the current knowledge on these risk factors of acquired LQTS, with an emphasis on non genetic risk factors, including environmental factors. PubMed was searched for literature in English from 1999 to 2011 on the molecular and clinical studies of Long-QT syndrome. We agree, with recent investigations described in the literature, that variety of factors, inherited or environmental, can influence expression of ion channel proteins with impact on repolarization.