TITLE:
Research Advances in the Prevention of Postoperative Anastomotic Leakage in Colorectal Cancer
AUTHORS:
Yunlong Weng, Kezeng Huang
KEYWORDS:
Colorectal Neoplasms, Anastomotic Leakage, Prevention
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.11,
November
24,
2025
ABSTRACT: According to the 2022 Global Cancer Statistics, colorectal cancer ranked third in new cancer cases and second in cancer-related deaths globally in 2022. Surgical treatment is a key treatment modality for patients with colorectal cancer. Although significant advancements have been made in surgical techniques, perioperative interventions, and treatment measures over the years, postoperative complications such as anastomotic leakage, intra-abdominal infection, and poor incision healing still inevitably occur. Among these, colorectal anastomotic leakage (CAL) is a particularly severe surgical complication, with an incidence rate as high as 30%. The occurrence of anastomotic leakage can lead to intra-abdominal and systemic infections, prolonged hospital stay, increased medical burden, worsened prognosis, and decreased survival rate in patients. Additionally, anastomotic leakage is a significant contributing factor to reoperation within 30 days after laparoscopic colorectal cancer resection, with a reoperation rate of 64.8%. Therefore, the prevention of postoperative anastomotic leakage in colorectal cancer is particularly important. This article reviews the research progress in the clinical prevention of postoperative anastomotic leakage in colorectal cancer.