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Katis, V.L., Lipp, J.J., Imre, R., et al. (2010) Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis. Developmental Cell, 18, 397-409. doi:10.1016/j.devcel.2010.01.014

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• TITLE: Irr1/Scc3 cohesin interacts with Rec8 in meiotic prophase of Saccharomyces cerevisiae

  AUTHORS: Agata Cena, Piotr Kowalec, Danuta Płochocka, Anna Kurlandzka

  KEYWORDS: Irr1/Scc3; Cohesin; Rec8; Meiosis; Saccharomyces cerevisiae

  JOURNAL NAME: Open Journal of Genetics, Vol.2 No.1, March 2, 2012

  ABSTRACT: The meiotic cohesin complex of S. cerevisiae shares with the mitotic one the Irr1/Scc3, Smc1, and Smc3 subunits, while the meiosis-specific subunit Rec8 replaces mitotic subunit Scc1/Mcd1. We noticed earlier that the irr1-1 mutation (F658G) severely affected meiosis. The irr1 1/IRR1 cells were entering meiosis before having completed mitotic cell division. Using meiotic two-hybrid assay and co-immunoprecipitation we show that in cells arrested in pachytene due to a lack of a gene-regulatory factor Ndt80, the Irr1 protein interacts with Rec8p and the irr1-1 mutation abolishes this interaction. These findings indicate an important role of Irr1p in early stages of meiosis.