TITLE:
Sertoli Cell Ovarian Tumor in a 59-Year-Old Postmenopausal Woman: A Case Report and Literature Review
AUTHORS:
Basma Aabboub, Abir Oufrid, Lamiae Amaadour, Karima Oualla, Zineb Benbrahim, Samia Arifi, Nawfel Mellas
KEYWORDS:
Ovarian Tumor, Sertoli Cell Tumor, Sertoli-Leydig Cell Tumor, Postmenopausal Woman, Adjuvant Chemotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.16 No.11,
November
20,
2025
ABSTRACT: Sertoli-Leydig cell tumors of the ovary are exceedingly rare, whereas Sertoli cell tumors represent an even more exceptional histological subtype. Sertoli cell tumors predominantly occur in young or middle-aged women, while Sertoli-Leydig cell tumors are typically diagnosed in younger patients. In both entities, postmenopausal presentation is uncommon. We report the case of a 59-year-old woman, postmenopausal for eight years, who presented with pelvic pain. Imaging revealed a heterogeneous right adnexal mass adjacent to the uterus. The patient underwent curative surgery consisting of exploratory laparotomy, total hysterectomy, and bilateral salpingo-oophorectomy. The tumor was staged as FIGO stage IC2. Histopathological examination confirmed a Sertoli cell tumor. No clinical evidence of a hormone-secreting syndrome was observed, particularly no postmenopausal bleeding, supporting the non-functional nature of the tumor. The patient received six cycles of adjuvant chemotherapy with carboplatin and paclitaxel, with a favorable postoperative outcome and follow-up.