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Bacci, G., Bertoni, F., Longhi, A., Ferrari, S., Forni, C., Biagini, R., et al. (2003) Neoadjuvant Chemotherapy for High-Grade Central Osteosarcoma of the Extremity: Histologic Response to Preoperative Chemotherapy Correlates with Histologic Subtype of the Tumor. Cancer, 97, 3068-3075.
https://doi.org/10.1002/cncr.11456

has been cited by the following article:

• TITLE: Curative Outcome of Osteosarcoma with Associated Pleural Effusion: A Case Report—Bone Tumor with Pleural Effusion in an Adolescent

  AUTHORS: Ahmed Dervis

  KEYWORDS: Osteosarcoma, Pleural Effusion, Adolescent, Bone Tumor, Case Report, Limb-Salvage Surgery

  JOURNAL NAME: Open Journal of Respiratory Diseases, Vol.15 No.4, November 19, 2025

  ABSTRACT: Background: Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Pulmonary metastasis is frequent, but pleural effusion is an unusual and challenging concomitant finding. We present a case of osteosarcoma with pleural effusion, managed successfully with multimodal therapy, and no recurrence after 3 years of follow-up. Case Presentation: We report a 17-year-old boy with osteosarcoma of the distal femur and reactive left-sided pleural effusion. The patient underwent thoracentesis followed by neoadjuvant chemotherapy, limb-salvage surgery, and adjuvant chemotherapy. The effusion resolved and did not recur. Conclusion: This case highlights that pleural effusion may accompany bone tumors even without metastasis, and that multidisciplinary management can achieve excellent outcomes.