TITLE:
Primary Squamous Cell Carcinoma of the Breast: A Case Report
AUTHORS:
Lalaina Nomenjanahary, Zo Irène Raivoherivony, Vahatra Joëlle Razafimahefa, Nantenaina Soa Randrianjafisamindrakotroka
KEYWORDS:
Breast Cancer, Cytokeratin, Estrogen Receptor, Progesterone Receptor, Squamous Cell Carcinoma
JOURNAL NAME:
Open Journal of Pathology,
Vol.16 No.1,
November
18,
2025
ABSTRACT: Primary squamous cell carcinoma of the breast is rare. We report a case of primary squamous cell carcinoma of the breast. It is a 47-year-old woman. She has an ulcerated, budding mass measuring 11 cm in diameter in the right breast. She underwent a right mastectomy. The diagnosis was non-keratinizing, moderately differentiated squamous cell carcinoma of the breast, stage IIIB invasive. Immunohistochemical testing was negative for estrogen and progesterone receptors but positive for cytokeratin CK 5/6. Diagnosis is histological and it is important to differentiate its primary breast origin from skin tumors or metastases from other organs.