TITLE:
Renal Transplant in a Hypersensitive Patient: A Case Report
AUTHORS:
Cristian León-Rabanal, Luis Zegarra-Montes, Rodrigo Castro de la Mata Guerra-García, Justo Dueñas-Chuquimia, Estefano Marcelo Benites, Andrea Valdez
KEYWORDS:
HLA Hypersensitivity, Desensitization, Renal Transplants
JOURNAL NAME:
Open Journal of Nephrology,
Vol.15 No.4,
November
11,
2025
ABSTRACT: In hypersensitized patients, Kidney Transplant (KT) rates are low due to the risk of organ loss due to rejection. Desensitization (DS) protocols have been developed to prevent rejection, increasing their success. We present the case of a 65-year-old female patient with Chronic Kidney Disease (CKD) associated with Hypertensive Nephroangiosclerosis (HNA) on Hemodialysis (HD). She was documented to have hypersensitization against Human Leukocyte Antigen (HLA), presenting Donor-Specific Antibodies (DSA) detected by solid-phase techniques, making her a high-immunological risk patient. With a suitable living donor available, a desensitization protocol was initiated. DS treatment consisted of plasmapheresis, Intravenous Immunoglobulin (IVIG) and Rituximab, with a successful KT result.