TITLE:
Pathological Interaction Mechanisms between Cervical Mycoplasma and Chlamydia Infections and Endometriosis: Novel Clinical Management Strategies
AUTHORS:
Zhaodong Wei, Cunjian Yi
KEYWORDS:
Endometriosis (EMs), Immune Dysregulation, Chronic Inflammation, Mycoplasma and Chlamydia Infections
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.11,
November
11,
2025
ABSTRACT: Endometriosis (EMs), a prevalent chronic inflammatory disease among women of reproductive age, has a global prevalence of 10% - 15% and is closely associated with 30% - 50% of infertility cases. This review systematically examines the epidemiological characteristics and molecular pathogenesis of EMs, establishing for the first time a dynamic interaction model between cervical mycoplasma and chlamydia infections in the pathological progression of EMs. Based on epidemiological correlation analysis, it reveals the spatiotemporal association between genital tract infections and EMs onset. By examining inflammatory pathway interactions, immune dysregulation, and microbiome imbalance, it elucidates the potential infection-inflammation-endometriosis “pathological vicious cycle”. Clinically, it innovatively proposes a “dual-track treatment” strategy integrating targeted hormone therapy, precision anti-infective regimens, and combined immune-microbiome modulation. This review constructs a precision prevention and treatment system through a translational medicine perspective. It not only achieves a paradigm shift in diagnosis and treatment from “symptom control” to “etiological intervention” but also provides EM patients with personalized treatment pathways based on molecular subtyping. This breakthrough offers a novel methodological framework for addressing treatment resistance and recurrence prevention in EM.