TITLE:
Rare Presentation of Small Bowel Undifferentiated Pleomorphic Sarcoma with Perforation and Obstruction
AUTHORS:
Tyng Shiuan Tung, Nusaibah Binti Azman, Mohamed Arif Hameed Sultan
KEYWORDS:
Gastrointestinal Stromal Tumour, Gastrointestinal Motility, Interstitial Cell of Cajal, Tyrosine Kinase Inhibitor, Immunohistochemistry
JOURNAL NAME:
Open Access Library Journal,
Vol.12 No.11,
November
7,
2025
ABSTRACT: Undifferentiated pleomorphic sarcoma (UPS) of the small intestine is extremely rare, with few cases including both obstruction and perforation. We discuss a case of small bowel UPS with acute perforation and luminal obstruction, focusing on diagnostic problems, surgical therapy, and pathological findings. Small intestine UPS is an uncommon tumor, and vague symptoms may cause delays in diagnosis. Imaging may indicate a malignant small bowel tumor; however, it cannot distinguish UPS from gastrointestinal stromal tumor, lymphoma, or adenocarcinoma. The simultaneous occurrence of perforation and blockage is unusual and presents management concerns. Complete surgical resection with negative margins is the primary treatment option; the role of adjuvant chemotherapy or radiotherapy is unknown because to a lack of data. The prognosis is generally poor, with a high recurrence and metastasis rate. This case report emphasizes the importance of being aware that undifferentiated pleomorphic sarcoma, albeit rare in the small intestine, can present tragically with perforation and obstruction. Prompt surgical intervention and a comprehensive pathologic examination are required. Additional case reports and studies are required to advise appropriate care and better understand the behavior of such tumors in the gastrointestinal tract.