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Ward, E.S., Gelinas, D., Dreesen, E., Van Santbergen, J., Andersen, J.T., Silvestri, N.J., Kiss, J., Sleep, D., Rader, D., Kastelein, J., Louagie, E., Vidarsson, G. and Spriet, I. (2022) Clinical Significance of Serum Albumin and Implications of Fcrn Inhibitor Treatment in Igg-Mediated Autoimmune Disorders. Frontiers in Immunology, 13.
https://doi.org/10.3389/fimmu.2022.892534

has been cited by the following article:

• TITLE: Low Serum Albumin as a Determinant of Mortality in Shock: A Systematic Review and Meta-Analysis of Global Evidence

  AUTHORS: Jackson Rashid Djuma, Claudine Malonga, Deogratias Mulungulungu, Marc Habunamboka Kilonda, Jean Charles Preiser

  KEYWORDS: Hypoalbuminemia, Shock, Mortality

  JOURNAL NAME: Open Journal of Emergency Medicine, Vol.13 No.4, November 7, 2025

  ABSTRACT: Background: Hypoalbuminemia is a hallmark of critical illness, reflecting both systemic inflammation and impaired homeostasis. This systematic review and meta-analysis examine the prognostic significance of low serum albumin in shock patients, integrating data from diverse global cohorts. Methods: Comprehensive searches of PubMed, Europe PMC, and Google Scholar were conducted (2019-2025) to identify studies reporting adjusted odds ratios (ORs) or hazard ratios (HRs) for the association between hypoalbuminemia and mortality in adult shock patients. Separate random-effects meta-analyses were performed for ORs and HRs. Heterogeneity was quantified with I2 statistics, and meta-regression was applied to explore study-level covariates. Results: Eleven studies met inclusion criteria (n = 7 OR studies; n = 4 HR studies). Pooled ORs and HRs each demonstrated a robust association between low serum albumin and increased mortality, independent of major confounders. Sensitivity analyses confirmed the stability of findings. Age significantly modified OR-based associations, while continental location showed borderline influence in HR models. Conclusions: Low serum albumin is a powerful, independent prognostic biomarker in shock. These findings reinforce albumin’s potential utility in risk stratification and therapeutic decision-making in critical care.