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Ashraf, M.A., Shen, B., Raza, M.A., Yang, Z., Amjad, M.N., Din, G.U., Yue, L., Kousar, A., Kanwal, Q. and Hu, Y. (2025) Albumin: A Review of Market Trends, Purification Methods, and Biomedical Innovations. Current Issues in Molecular Biology, 47, Article 303.
https://doi.org/10.3390/cimb47050303

has been cited by the following article:

• TITLE: Low Serum Albumin as a Determinant of Mortality in Shock: A Systematic Review and Meta-Analysis of Global Evidence

  AUTHORS: Jackson Rashid Djuma, Claudine Malonga, Deogratias Mulungulungu, Marc Habunamboka Kilonda, Jean Charles Preiser

  KEYWORDS: Hypoalbuminemia, Shock, Mortality

  JOURNAL NAME: Open Journal of Emergency Medicine, Vol.13 No.4, November 7, 2025

  ABSTRACT: Background: Hypoalbuminemia is a hallmark of critical illness, reflecting both systemic inflammation and impaired homeostasis. This systematic review and meta-analysis examine the prognostic significance of low serum albumin in shock patients, integrating data from diverse global cohorts. Methods: Comprehensive searches of PubMed, Europe PMC, and Google Scholar were conducted (2019-2025) to identify studies reporting adjusted odds ratios (ORs) or hazard ratios (HRs) for the association between hypoalbuminemia and mortality in adult shock patients. Separate random-effects meta-analyses were performed for ORs and HRs. Heterogeneity was quantified with I2 statistics, and meta-regression was applied to explore study-level covariates. Results: Eleven studies met inclusion criteria (n = 7 OR studies; n = 4 HR studies). Pooled ORs and HRs each demonstrated a robust association between low serum albumin and increased mortality, independent of major confounders. Sensitivity analyses confirmed the stability of findings. Age significantly modified OR-based associations, while continental location showed borderline influence in HR models. Conclusions: Low serum albumin is a powerful, independent prognostic biomarker in shock. These findings reinforce albumin’s potential utility in risk stratification and therapeutic decision-making in critical care.