TITLE:
Transient Aplastic Crisis Associated with Parvovirus B19 Infection in a Patient with Pernicious Anemia and Hemolysis
AUTHORS:
Flávia Fundora Ramos, Catarina Pinto Silva, Dany Cruz, Beatriz Rosa, Pilar Barbeito Barral, Carlos Oliveira
KEYWORDS:
Aplastic Crisis, Parvovirus B19, Pernicious Anemia, Hemolysis
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.14 No.11,
November
6,
2025
ABSTRACT: Introduction: Parvovirus B19 is a human erythrovirus that causes variable clinical manifestations depending on the host’s immunological and hematological status. In patients with underlying hematological disorders, it can trigger transient aplastic crisis. Case Description: A 68-year-old man with a history of type 2 diabetes mellitus, chronic gastritis, and anemia under investigation presented with progressive fatigue, anorexia, and weight loss. Physical examination revealed cutaneous-mucosal pallor and pancytopenia with severe vitamin B12 deficiency, direct hyperbilirubinemia, and haptoglobin Discussion: This case illustrates the importance of early recognition of Parvovirus B19 infection as a cause of transient aplastic crisis in patients with underlying pernicious anemia. Appropriate clinical suspicion can prevent unnecessary invasive procedures, as aplasia is transient and responds to supportive measures.