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Chen, Y., Cho, Y., Chang, C. and Chu, C. (2013) Drug Reaction with Eosinophilia and Systemic Symptoms: A Drug-Induced Hypersensitivity Syndrome with Variable Clinical Features. Dermatologica Sinica, 31, 196-204.
https://doi.org/10.1016/j.dsi.2013.09.006

has been cited by the following article:

• TITLE: Hypersensitivity Reaction to Lamotrigine with Rash and Cervical Adenopathies: A Case Report

  AUTHORS: Flávia Fundora Ramos, Catarina Pinto Silva, Flávia Freitas, Laura Caine

  KEYWORDS: Lamotrigine, Adverse Drug Reaction, Hypersensitivity, Drug-Induced Rash, Cervical Adenopathy

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.14 No.11, November 6, 2025

  ABSTRACT: Introduction: Lamotrigine is an anticonvulsant widely used in the treatment of epilepsy and affective disorders. Despite its favorable safety profile, potentially serious hypersensitivity reactions can occur. Case Report: A female patient in her early thirties developed a lupus-like maculopapular rash and painful cervical adenopathy after three weeks of treatment with lamotrigine. Laboratory tests revealed initial lymphopenia and slightly increased IgG. Serology for hepatotropic viruses, HIV, CMV, and EBV (IgM) was negative. Computed tomography revealed bilateral level II cervical adenopathy and a thin layer of pericardial effusion. The condition was interpreted as a hypersensitivity reaction to lamotrigine, which resolved after discontinuation of the drug and oral corticosteroid therapy. Conclusion: Rash associated with adenopathy in the first weeks of lamotrigine use should raise suspicion of a serious adverse reaction and justify immediate discontinuation of the drug.