TITLE:
Materno-Fetal Prognosis and Factors Associated with Neonatal Death after Preterm Premature Rupture of Membranes at More than 28 Weeks Gestation in Yaoundé, Cameroon
AUTHORS:
William Derrick Zambo Zambo, Serge Guifo Foubi, Véronique Mboua Batoum, Junie Metogo Ntsama, Felix Essiben, Evelyn Mah Mungyeh, Esther Ngo Um Meka
KEYWORDS:
Premature Rupture of Membranes, Maternal Complications, Neonatal Mortality
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.15 No.10,
October
28,
2025
ABSTRACT: Introduction: Premature rupture of membranes (PROM) causes considerable maternal and perinatal morbidity and mortality. Adequate management is therefore essential to reduce the complications associated with it. The main objective of our study was to determine the maternofetal and neonatal outcomes after a pregnancy complicated by PPROM, as well as the factors associated with neonatal death in this context. Methodology: We conducted a descriptive and analytical longitudinal study on a population of pregnant women with PPROM who gave their free and informed consent. Newborns were assessed from birth until the 7th day of life. The association between study variables and neonatal death was established using the chi-square test and expressed as odds ratios with a p-value Results: A total of 115 women met the inclusion criteria, corresponding to an incidence of premature rupture of membranes of 6.18%. Maternal complications were dominated by threatened preterm labor (50.9%), caesarean deliveries (25%), retroplacental haematoma (3.6%) and intrauterine infections (6.3%). Fetal and early neonatal outcomes were most commonly characterised by early neonatal infections (73.14%), prematurity (52.8%), respiratory distress (5.6%), neonatal asphyxia (2.8%) and neonatal death (12.9%). After multivariate analysis by logistic regression, the only factor that remained associated with the occurrence of neonatal death was an Apgar score Conclusion: The maternofetal and neonatal prognosis after PPROM remains poor in our setting due to multiple maternal and perinatal factors.