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Amodio, N., Scrima, M., Palaia, L., Salman, A.N., Quintiero, A., Franco, R., et al. (2010) Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas. The American Journal of Pathology, 177, 2622-2634.
https://doi.org/10.2353/ajpath.2010.091075

has been cited by the following article:

• TITLE: Nedd4-1 as a Proliferating Factor in Uterine Cervical Carcinogenesis

  AUTHORS: Soohyun Oh, Jin Woo Shin

  KEYWORDS: Apoptosis, Carcinogenesis, Cervical Cancer, Nedd4-1, Proliferation

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.15 No.10, September 30, 2025

  ABSTRACT: Objective: Nedd4-1 has been reported to be overexpressed in various human cancers. In this study, we investigated the role of Nedd4-1 in carcinogenesis and prognosis of cervical cancer. Methods: We reviewed formalin-fixed paraffin-embedded tissue blocks from radical hysterectomy for cervical cancer from 2007 to 2008. A total of 49 paraffin blocks were included if they had either normal epithelium or cervical intraepithelial neoplasia (CIN) III along with cancer tissue in the same blocks. Immunohistochemical staining was performed, and overexpression was defined by both intensity and proportion of positive cells. The patients were retrospectively followed up for assessing progression-free survival (PFS) and overall survival (OS) in relation to Nedd4-1 expression. Additionally, to investigate the effect of Nedd4-1 expression in cervical cells, MTT assay and flow cytometry were used for HeLa and CaSki cells treated with Nedd4-1 and control siRNA. Results: Among 49 blocks, overexpression of Nedd4-1 was observed in 15.6% of normal epithelium, 37.1% of CIN III, and 79.6% of cancer and the differences were statistically significant (p Conclusions: Overexpression of Nedd4-1 is possibly associated with carcinogenesis of cervical cancer. Nevertheless, its prognostic significance needs to be investigated further.