TITLE:
Prevalence of Dengue Serological Markers among Febrile Patients at Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), Burkina Faso
AUTHORS:
Abdoul Karim Ouattara, Denise P. Ilboudo, Tani Sagna, Albert Théophane Yonli, Atassim Koffi Yabe Ali, Jacques Simporé
KEYWORDS:
NS1 Antigen, IgM, IgG, Febrile Patients, Burkina Faso
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.15 No.3,
September
29,
2025
ABSTRACT: Dengue virus infection is a major public health concern in endemic regions, including Burkina Faso, where data on seroprevalence and progression are limited. This study aimed to evaluate the seroprevalence and dynamics of dengue virus infection among suspected febrile patients at CERBA. A descriptive analytical study was conducted from January to September 2023, including 4484 patients who underwent dengue serological testing. Venous blood samples were processed to detect NS1 Ag, IgM, and IgG antibodies using the SD Bioline Dengue Duo Rapid Detection Kit. Data were analyzed with SPSS v26.0 using multivariate logistic regression, with statistical significance set at p +, 18.2% IgM+, and 36.8% IgG+. NS1 Ag positivity was highest in the 16 - 30 age group (57.3%), while IgG positivity peaked in individuals aged > 46 years. September recorded 83.5% of suspected cases, with 54.5% NS1 Ag positivity. Multinomial regression revealed that individuals aged 16 - 30 were significantly more likely to test positive for NS1 Ag (OR = 1.487, p = 0.002) compared to children under five years, while those > 65 years were less likely (OR = 0.517, p = 0.005). This study highlights the high dengue seroprevalence among suspected febrile cases in Ouagadougou, with significant age-related variability and seasonal trends, emphasizing the need for targeted surveillance and preventive measures.