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N. Rodondi, W. P. den Elzen, D. C. Bauer, A. R. Cappola, S. Razvi, J. P. Walsh, B. O. Asvold, G. Iervasi, M. Imaizumi, T. H. Collet, A. Bremner, P. Maisonneuve, J. A. Sgarbi, K. T. Khaw, M. P. Vanderpump, A. B. Newman, J. Cornuz, J. A. Franklyn, R. G. Westendorp, E. Vittinghoff and J. Gussekloo, “Subclinical Hypothyroidism and the Risk of Coronary Heart Disease and Mortality,” Journal of the American Medical Association (JAMA), Vol. 304, No. 12, 2010, pp. 1365-1374. doi:10.1001/jama.2010.1361

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• TITLE: Subclinical Hypothyroidism in Children Can Normalize after Changes in Dietary Intake

  AUTHORS: Marjolein W. J. Kuiper, Ellen J. van der Gaag

  KEYWORDS: Subclinical Hypothyroidism; TSH, BMI; Vitamin A; Dairy Products; Beef; Vegetables

  JOURNAL NAME: Food and Nutrition Sciences, Vol.3 No.3, March 21, 2012

  ABSTRACT: Background: There is no effective treatment for children with subclinical hypothyroidism. The natural course of subclinical hypothyroidism shows a normalization rate of 41% for Thyroid Stimulating Hormone (TSH). Objective; The thyroid needs (among others) iron, iodine, and vitamin A for a proper thyroid hormone synthesis. We hypothesize that with a dietary change, more children can normalize their TSH. Design: In this case-control study, 54 children aged 1 - 14 years with subclinical hypothyroidism were divided into a diet group and a control group. The diet consisted of green vegetables, beef, full fat milk, and butter. The diet was followed for at least 3 months. A total of 27 patients comprised the diet group and 27 the control group. TSH, Free T4 (FT4), and Body Mass Index (BMI) were evaluated during the follow up. Results: By following this diet, TSH levels decreased significantly compared to when following the natural course. FT4 levels did not change during the follow up. The diet group realized a change of normalizing their TSH with a RR 2.8 (95% CI 1.45 - 5.61). There were no changes in BMI after following the diet. Conclusions: Even though our study population was small, we observed the association of a dietary change and normalization of TSH in children with subclinical hypothyroidism, without adverse effects.