TITLE:
Fat Emulsion Extravasation-Induced Diabetic Foot Ulcers: Case Report and Literature Review
AUTHORS:
Lei Hao, Yuchen Wang, Jinben Yu, Leixuan Li, Tiewu Chen, Longbiao Xu
KEYWORDS:
Fat Emulsion Extravasation, Diabetic Foot Ulcer, Electroacupuncture, Ulcer Healing, Inflammation Relief, Pain Relief, Non-Drug Therapy, Microcirculation Improvement, Clinical Efficacy
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.14 No.9,
September
24,
2025
ABSTRACT: A case of Diabetic Foot Ulcer (DFU) induced by fat emulsion extravasation was treated with Electroacupuncture (EA) in combination with basic Fibroblast Growth Factor (bFGF) gel over an 8-week period. The findings demonstrated a significant reduction in local inflammation, acceleration of ulcer healing, notable alleviation of pain, and the absence of any adverse reactions. This case preliminarily suggests the potential effectiveness of EA in the management of DFU resulting from fat emulsion extravasation. However, these results require validation through larger-scale studies. Currently, the treatment of severe extravasation injury remains a subject of controversy. In summary, electroacupuncture, as a safe and straightforward non-drug therapeutic approach, may play a crucial role in the treatment of DFU caused by fat emulsion extravasation. Specifically, it can enhance local microcirculation, mitigate the inflammatory response, promote wound healing, and relieve pain. Future research should delve deeper into the mechanism of action and long-term efficacy to offer patients more treatment alternatives.