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Leitão, A.E., de Souza Vieira, M.C., Pelegrini, A., da Silva, E.L. and de Azevedo Guimarães, A.C. (2021) A 6-Month, Double-Blind, Placebo-Controlled, Randomized Trial to Evaluate the Effect of Eurycoma longifolia (Tongkat Ali) and Concurrent Training on Erectile Function and Testosterone Levels in Androgen Deficiency of Aging Males (Adam). Maturitas, 145, 78-85.
https://doi.org/10.1016/j.maturitas.2020.12.002

has been cited by the following article:

• TITLE: Herbal Therapies for Male Sexual Health: A Comprehensive Review of Clinical Evidence and Mechanisms

  AUTHORS: Shengjie Zhu, Meiling Li, Huijun Z. Ring

  KEYWORDS: Testosterone, Libido, TCM, Yang Tonic, Kidney Deficiency, Herbal Medicine, Male Sexual Health

  JOURNAL NAME: Health, Vol.17 No.9, September 23, 2025

  ABSTRACT: Age-related sexual dysfunction and testosterone decline in men are common conditions that affect quality of life and well-being. Herbal therapies, particularly those rooted in Traditional Chinese Medicine (TCM), are gaining popularity as natural alternatives to hormone replacement therapy. This review synthesizes evidence from eight double-blind randomized controlled trials evaluating herbal interventions for male sexual health, including Eurycoma longifolia (Tongkat Ali), Lepidium meyenii (Maca), Trigonella foenum-graecum (Fenugreek/Testofen), and a multi-herb topical SS-cream. Findings suggest that these therapies improve sexual function through both hormone-related and hormone-independent mechanisms. Across studies, adverse events were mild and comparable to placebo. In addition to biomedical mechanisms—such as hypothalamic-pituitary-gonadal (HPG) axis support and nitric oxide (NO) signaling—these herbs align with TCM concepts of yang-tonification, kidney support, and essence nourishment, highlighting their potential as integrative options for male sexual health.