TITLE:
Reference Values for Coagulation Parameters in Canine and Feline Species Assessed by the Horiba Yumizen G200: A Tool for Clinical Interpretation in Veterinary Medicine
AUTHORS:
Daniele Pacheco, Bárbara Lima, Rafael Gonçalves Dias, Guilherme de Oliveira Meirelles, Bruno Monteiro da Silva, Letícia Eiki Kikuta, Camila Aparecida de Almeida Maia, Juliana Falcato Vecina
KEYWORDS:
Coagulopathies, Thrombocytopenias, Coagulation Profile, Fibrinogen, D-Dimer, Hemostasis Analyzer, Dogs, Cats
JOURNAL NAME:
Open Journal of Veterinary Medicine,
Vol.15 No.9,
September
18,
2025
ABSTRACT: Bleeding is a common clinical finding in animals and is often associated with one or more alterations in the hemostatic system. In dogs, the most frequent causes include thrombocytopenia, disseminated intravascular coagulation (DIC), and rodenticide toxicity. In contrast, these conditions are less common in cats, where hemorrhagic manifestations are more frequently linked to hepatic disorders, feline infectious peritonitis (FIP), and neoplasms. Congenital coagulopathies are considered rare in both species. Unlike in human medicine, coagulation profiles are infrequently utilized in veterinary practice, and the existing literature primarily comprises isolated case reports. In this context, the present study aimed to evaluate the performance of a semi-automated coagulation analyzer (Yumizen G200—Horiba) using canine and feline samples, with the objective of proposing a laboratory protocol suitable for implementation in routine veterinary clinical practice. For this purpose, blood samples were collected from clinically healthy animals, comprising 140 dogs and 44 cats of both sexes and adult age, after applying the exclusion criteria. The parameters analyzed included prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen concentration (FIB). One of the main challenges encountered during the study was the recruitment of truly healthy animals, as patients referred for clinical evaluation are typically those presenting with underlying health conditions. The results obtained are consistent with the limited literature available on hemostatic parameters in animals, and they demonstrate the efficacy of the analyzer for conducting such evaluations. Therefore, the establishment of reference intervals, alongside the integration of this equipment into veterinary practice, represents a significant advancement in both the quality and efficiency of diagnosing various coagulopathies.