TITLE:
Research Progress on Treatment Strategies for Rebleeding Esophageal and Gastric Varices in Cirrhosis
AUTHORS:
Shanshan Lan, Chuanxin Zou
KEYWORDS:
Cirrhosis, Portal Hypertension, Esophageal and Gastric Variceal Bleeding, Drug Therapy, Endoscopic Therapy, Interventional Therapy, Individualized Therapy, Therapeutic Advances
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.9,
September
11,
2025
ABSTRACT: This article provides a systematic review of comprehensive treatment strategies for esophagogastric variceal bleeding in portal hypertension. For pharmacological treatment, nonselective β-blockers (e.g., carvedilol) and vasoactive agents (e.g., terlipressin) reduce portal pressure and improve hemostasis through distinct mechanisms. Endoscopic treatments include variceal ligation (EVL) and cyanoacrylate injection for esophageal and gastric varices, respectively. Regarding interventional therapy, early transjugular intrahepatic portosystemic shunt (TIPS) can significantly improve prognosis in high-risk patients. Additionally, individualized treatment strategies based on etiology, Child-Pugh classification, and hemodynamic assessment are becoming a clinical focus. Future research should prioritize optimizing combination therapies and expanding applications of novel interventional techniques. This article integrates current evidence to provide systematic guidance for clinical decision-making.