TITLE:
High-Grade B-Cell Lymphoma in a Newly Diagnosed HIV Patient with Near-Normal CD4 Count: A Diagnostic Challenge
AUTHORS:
Hind Hamid Alrowais, Khalid Maddi Alqhatani, Hanan Mohamed Moalim Abdullahi, Gamal Thabet Aly Ebid, Essam Iotfy Abdelhamid Eid, Waleed Amasaib Ahmed
KEYWORDS:
HIV-Associated Lymphoma, High-Grade B-Cell Lymphoma, CD4 Count, Diagnostic Challenge, Immune Preservation, Non-Hodgkin lymphoma
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.15 No.3,
September
8,
2025
ABSTRACT: We present a rare case of a 27-year-old male with newly diagnosed HIV infection who presented with systemic symptoms, generalized lymphadenopathy, hepatosplenomegaly, and multi-organ involvement, ultimately found to have high-grade lymphoma. Notably, despite his advanced clinical presentation, his CD4 count was nearly normal (380 cells/μL), challenging the typical immunopathogenic understanding of HIV-associated lymphomas. This case highlights the importance of maintaining a high index of suspicion for malignancy even in the setting of relatively preserved immune status in HIV-positive individuals.