TITLE:
Outcome in Newborns of Mothers with Sickle Cell Disease in Ouagadougou, Burkina Faso: A Retrospective Study from 2019 to 2023
AUTHORS:
Caroline Yonaba/Okengo, Lassina Dao, Ima Theophane, Oumarou Sawadogo, Hyacinthe Zamane, Angèle Zongo, François Millogo, Fla Koueta
KEYWORDS:
Sickle Cell, Mother, Newborn, Ouagadougou
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.15 No.5,
September
8,
2025
ABSTRACT: Sickle cell disease affects 5% to 10% of the population in Burkina Faso. There has been remarkable progress in reducing mortality associated with this condition. However, survival in pregnant women with sickle cell disease is still a challenge. Moreover, little is known of the outcome of their children in the early moment of life. A retrospective study was conducted from January 1, 2019 to December 31, 2023. Newborns born at Yalgado Ouedraogo hospital’s maternity whose mothers had a major sickle cell syndrome were included. A bivariate and multivariate analysis was used to determine factors associated with newborn deaths (P-value ≤ 5%). A total of 656 newborns were included, with an annual frequency of 141. Mothers’ mean age was 26 years, 91% had hemoglobin SC and 21% had vaso-occlusive crisis at admission in the maternity ward. Newborns were males in 51%, and the mean birth weight of newborns was 2705 g [extremes 845 and 4700 g]. In multivariate analysis, factors significantly associated with neonatal deaths were maternal vaso-occlusive crisis on admission (OR = 3.39; P-value = 0.032), low birth weight (P-value = 0.027), acute respiratory distress (P-value = 0.011) and prematurity (P-value = 0.018) in newborns.