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Van Coppernolle, S., Verstichel, G., Timmermans, F., Velghe, I., Vermijlen, D., De Smedt, M., Leclercq, G., Plum, J., Taghon, T., Vandekerckhove, B. and Kerre, T. (2009) Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells. Journal of Immunology, 183, 4859-4870. doi:10.4049/jimmunol.0900714

has been cited by the following article:

• TITLE: Innate-like CD4 T cells selected by thymocytes suppress adaptive immune responses against bacterial infections

  AUTHORS: Yu Qiao, Brian M. Gray, Mohammed H. Sofi, Laura D. Bauler, Kathryn A. Eaton, Mary X. D. O’Riordan, Cheong-Hee Chang

  KEYWORDS: Bacterial Infection; Innate-Like CD4 T Cells; Immune Suppression

  JOURNAL NAME: Open Journal of Immunology, Vol.2 No.1, March 19, 2012

  ABSTRACT: We have reported a new innate-like CD4 T cell population that expresses cell surface makers of effector/memory cells and produce Th1 and Th2 cytokines immediately upon activation. Unlike conventional CD4 T cells that are selected by thymic epithelial cells, these CD4 T cells, named T-CD4 T cells, are selected by MHC class II expressing thymocytes. Previously, we showed that the presence of T-CD4 T cells protected mice from airway inflammation suggesting an immune regulatory role of T-CD4 T cells. To further understand the function of T-CD4 T cells, we investigated immune responses mediated by T-CD4 T cells during bacterial infection because the generation of antigen specific CD4 T cells contributes to clearance of infection and for the development of immune memory. The current study shows a suppressive effect of T-CD4 T cells on both CD8 and CD4 T cell-mediated immune responses during Listeria and Helicobacter infections. In the mouse model of Listeria monocytogenes infection, T-CD4 T cells resulted in decreasedfrequency of Listeria-specific CD8 T cells and the killing activity of them. Furthermore, mice with T-CD4 T cells developed poor immune memory, demonstrated by reduced expansion of antigen-specific T cells and high bacterial burden upon re-infection. Similarly, the presence of T-CD4 T cells suppressed the generation of antigen-specific CD4 T cells in Helicobacter pylori infected mice. Thus, our studies reveal a novel function of T-CD4 T cells in sup-pressing anti-bacterial immunity.